In-Vivo technical platform
& available imaging modalities

Voxcan provides several Imaging technologies: Anatomical Imaging (CT & µ-CT scan) and Functional imaging (Bioluminescence & Fluorescence Tomography) with different techniques to manage and analyze the images and efficiently characterize the effect of the compounds tested for our Customers.

In order to bring to our customer a complementary information about the efficacy, biodistribution of treatments as well as the evaluation of tumor kinetics, we have the capacity to combine several imaging techniques in parallel to consolidates the data and can help in the confirmation of the conclusion of a study

Animal housing and Biosecurity facilities

Voxcan has a total area of 400m² accredited animal facilities with a segregated ABSL-2 and ABSL-3 facilities. We have a capacity to accommodate different species:

  • Rodents including cotton rats
  • Lagomorphs
  • Ferrets
  • Poultries

Rodents are hosted in ventilated racks (with irradiated single-use cage), which creates a micro-environment and thus maintains health status of: SOPF (Specific and Opportunistic Pathogen Free) or SPF (Specific Pathogen Free). The accommodation of the other species is carried out in parks, which enables to create social groups.

Larger species can be housed by our partners and be addressed to Voxcan for in-vivo imaging analysis. The modern design of Voxcan’s facilities, our work processes, the controlled environment and the health control program including a comprehensive monitoring and scoring programs in place, all of them ensure consistency in our studies, while respecting the welfare of the animals.

Anatomical imaging

CT & µ-CT

X-ray computed tomography (CT) gives 3-dimensional images of naturally dense tissues or soft tissues made denser by the injection of a contrast agent.

 

 Such image acquisitions provide information of 3D anatomical characteristics deprived of slice bias for an optimal parameter quantification (length, surface, volume, curvature, thickness, density…).

  • Our X-ray CT scanner permits relevant image acquisitions on animal models from rabbit to 200kg pig (ring diameter of the scanner is 70cm). 3D images have resolution with a minimum pixel size of 180µm in the plane. Minimum slice thickness is 310µm.
  • Our micro X-ray scanner dedicated to rodent performs relevant image acquisitions on small animal models from mouse to guinea-pig (the useful tunnel diameter is 80mm) 3D images have an isotropic resolution in all three directions. Voxel sizes is 50µm and slice thickness too. Acquisition times range from 2 to 10 min depending on the protocol.
  • Our sample X-ray scanner provides acquisitions from 30µm to 6µm.

Functional imaging

 

Bioluminescence & Fluorescence Tomography

Optical molecular imaging allows the in-vivo detection of biochemical processes in small animal models.

  • Bioluminescence imaging permits the realization of efficacy studies in oncology, using luciferase + cancer cell lines, and in infectious diseases fields using luciferase + bacteria strains or viruses.
  • Fluorescence imaging gives access to in-vivo whole body biodistribution studies. This imaging technique is sufficiently sensitive on small animals (small rate of absorption and diffusion processes) and most molecule labeling processes remain easy to handle. Image resolutions range from 20µm to 2mm depending on the study. Two of our imaging systems can perform 2D or 3D acquisitions and a third one can also provide a bi-modal acquisition together with an X-ray radiography.

 

Surgical Platform

 

Our equipped surgery room, has an induction and recovery room, allows the realization of your models in the best conditions. The organization of the team, with an anesthesiologist who manages the surgeons, allows us to work under optimal aseptic conditions.